Ukraine and CERN signed an International Cooperation Agreement in 1993, and a Joint Declaration in 2011 concerning a possible application for associate membership of CERN, setting priorities in scientific and technical cooperation. Ukraine’s relationship with CERN dates back much further, principally through CERN’s cooperation with the Joint Institute of Nuclear Research (JINR) in Dubna, Russia, of which Ukraine was a member until 2022. 

Ukraine has been a long-time contributor to the ALICE, CMS and LHCb experiments at the LHC, and to research and development projects on new accelerator technologies. Ukraine also operates a Tier-2 computing centre in the World-wide LHC Computing Grid (WLCG) that federates globally distributed resources to process and analyse the massive amounts of data generated by the LHC experiments. In 2011 a joint declaration was signed  by CERN and the Minor Academy of Science of Ukraine concerning participation by Ukrainian teachers and students in CERN educational programmes.

Ukraine became an Associate Member State on 5 October 2016. 

Several actions have been initiated by CERN to support Ukraine since the invasion by the Russian Federation on 24 February 2022.